Case Study 208 – Cluster Headaches Cluster headaches are one of the most severe pain syndromes in medicine. The pain is sudden, excruciating, and one-sided, typically centered around or behind the eye, temple, or forehead. Patients describe it as stabbing, burning, or drilling pain that can feel unbearable. Unlike migraines, cluster headaches occur in clusters — multiple attacks per day over weeks to months — followed by periods of remission. Attacks are often predictable, striking at the same t

What Are Cluster Headaches? | IFLScience