Methotrexate Safety Checklist! Methotrexate is a powerful DMARD, but safe prescribing requires a strict protocol. Before you write your next prescription, are you following these essential steps? 1. Pre-Treatment Screening (Baseline): Rule out any active infections. Get baseline CBC, LFT, and RFT. 2. Initiating Therapy: Always start with a low test dose (e.g., 5mg) for the first week. Re-evaluate the patient after one week for any immediate side effects before escalating the dose. 3. Monitoring