Dec 12, 2022 · As myotonic dystrophy type 1 is passed from one generation to the next, the condition generally begins earlier and earlier in life, and signs and symptoms become more severe.

Sep 17, 1999 · Classic DM1 is characterized by muscle weakness and wasting, myotonia, cataract, and often cardiac conduction abnormalities; adults may become physically disabled and may have a …

Congenital DM1 is the most severe and earliest occurring form of myotonic dystrophy. It occurs when a mother, who often is not aware she has DM1, passes the mutation that causes DM1 onto her child.

Myotonic dystrophy type 1 (DM1) is a genetic, multisystem condition causing progressive muscle weakness, stiffness, and complications in the heart, lungs, and digestion. Learn about symptoms, …

DM is divided into two types. Type 1 DM (DM1), long known as Steinert disease, occurs when a gene on chromosome 19 called DMPK contains an abnormally expanded section located close to the …

It is the most common form of muscular dystrophy that begins in adulthood. [1] It was first described in 1909, with the underlying cause of type 1 determined in 1992. [2]

Feb 18, 2026 · Myotonic dystrophy type 1 is a rare, dominantly inherited, progressive, disabling, neuromuscular disease that leads to decreased life expectancy and has no approved therapies.

Sep 22, 2025 · Myotonic dystrophy type 1 (DM1) is a severe, inherited multisystem disorder with marked variability in age at onset, organ involvement and severity, often showing genetic anticipation...

There are two known forms of this disease (Myotonic Dystrophy Type 1 and Myotonic Dystrophy Type 2). Both are caused by abnormal expansions of repeated areas of genes.

The features of myotonic dystrophy often develop during a person's twenties or thirties, although they can occur at any age. The severity of the condition varies widely among affected people, even …