When cells proliferate, genomic DNA is precisely duplicated once per cell cycle. Abnormalities in this DNA replication ...
At each cell division in humans, DNA replication starts from 50,000 DNA replication origins, which are at specific locations along the chromosomes and from which DNA synthesis proceeds bidirectionally ...
Figure 1: Genetic analysis of the oriC DNA unwinding element reveals a critical region required for initiation activity. Figure 2: DnaA filaments are loaded from DnaA-boxes onto a specific ...
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