The relationship between inflammation and cancer represents one of the central paradoxes in modern tumor immunology. On one hand, chronic inflammation is a ...

Environmental and chemical exposures have emerged as critical contributors to the global cancer burden. Sources such as dietary contaminants, food ...

A newly discovered biological signal in the blood could help health care teams and researchers better understand how children respond to brain injuries at the cellular level, according to our research ...

Lacey W. Heinsberg receives funding from the National Institutes of Health. Amery Treble-Barna receives funding from the National Institutes of Health. A newly discovered biological signal in the ...

All the cells in an organism have the exact same genetic sequence. What differs across cell types is their epigenetics—meticulously placed chemical tags that influence which genes are expressed in ...

Nutritional epigenetics examines how maternal diet influences fetal gene expression through mechanisms such as DNA methylation, thereby shaping lifelong risks of metabolic, neurodevelopmental, and ...

Epigenetic alterations represent heritable yet reversible structural changes in histone or DNA. Protein arginine methylation, a common post-translational modification, is mediated by the protein ...

Summary: Researchers have shown for the first time that flipping an epigenetic “switch” in specific memory-holding neurons can directly alter memory strength. By targeting the gene Arc—which helps ...

Durable reprogramming of human T cells may now be possible thanks to a new technique based on the CRISPRoff and CRISPRon methodology. Researchers from the Arc Institute, Gladstone Institutes, and the ...

This figure shows primary T cells modified using two approaches. CAR receptors are introduced through targeted DNA insertion (top), while CRISPRoff mRNA and guide RNAs silence additional genes through ...

A new review in Clinical Epigenetics synthesises growing evidence that paternal lifestyle and environmental exposures such as diet, obesity, smoking, endocrine-disrupting chemicals, and stress alter ...