Currently, most therapies for allergic diseases require lifelong treatment. Allergic reactions, characterized by ongoing (type 2) inflammation in response to chronic antigen exposure, underlie many ...

Peter L. Salgo, MD: All of asthma, we’re going to lump it into 1 big economic burden. Whatever the cause, whatever the dust mites, or the allergens, or whatever the phenotype, at some point it’s ...

A research team embarked on a quest to understand the diversity and cellular mechanisms of human Th2 cells. By conducting gene expression analyses of inflamed tissues, they pinpointed a subset of Th2 ...

There has been a huge shift forward in the understanding of innate and adaptive immune mechanisms that provoke type 2 inflammation in atopic disease and eosinophilic esophagitis, according to a CHEST ...

Asthma is a chronic inflammatory condition marked by an imbalance in the immune response within the airways. According to Lancet, asthma affects around 339 million people globally. While conventional ...

Please provide your email address to receive an email when new articles are posted on . This study population represents patients with COPD and Th2 inflammation that clinicians treat daily. Included ...

Studies have demonstrated a critical role of the cytokines thymic stromal lymphopoietin (TSLP), IL-33, and IL-25, produced by epithelial and other cells at mucosal surfaces in response to a wide range ...

Immune-inflammatory skin diseases (e.g., psoriasis, atopic dermatitis) involve dysregulation of CD4+ T-cell subsets (Th1/Th2/Th17/Treg) and cytokine networks (IL-17/IL-23/IL-4). Biologics targeting ...

A new study in Cell Reports offers fresh evidence that fibroblasts actively shape inflammatory environments in skin disease. Using single-cell RNA sequencing and multiplexed error-robust fluorescence ...