Hailey-Hailey disease is a rare, inherited condition characterized by patches of blisters appearing mainly in the skin folds of the arm pits, groin and under the breasts. It is caused by a mutation in ...

Toward the goal of efficient editing of farm animals for genetic improvements, this study explores an upgraded form of nuclease PE (uPEn). Based on the resolved structure of the NiV polymerase L-P ...

Actin filaments - protein structures critical to living movement from single cells to animals - have long been known to have polarity associated with their physical characteristics, with growing ...

Researchers at the Indian Institute of Science and collaborators used cryo-EM to decode the molecular architecture of a transporter protein controlling the movement of gamma-aminobutyric acid (GABA).

Scientists from Scripps Research have uncovered new structures of transthyretin, a protein that moves important hormones like thyroxine through blood and spinal fluid. Misfolded versions of the ...

Using Cryo-EM, a powerful microscopy technique, researchers at IISc and collaborators have decoded the molecular architecture of a transporter protein controlling the movement of a key ...

Researchers at Vilnius University (Lithuania) have uncovered how the bacterial protein Cas9, better known as the CRISPR-Cas ...

Comparison of three water sites captured under various conditions demonstrates the power of cryo-neutron crystallography. Associated water molecules W1 (left), W6 (center), and W75 (right), were ...

Researchers show how LGP2 binds viral RNA ends, moves along the strand, and helps MDA5 form filaments that amplify antiviral signaling. The findings clarify an early defense step and may inform ...