Scientists at St. Jude Children's Research Hospital have characterized a hidden intermediate state at the center of Src kinase function. This hidden state allows the kinase to repeatedly modify its ...
Understanding neural protein phosphorylation and the role of different kinases and substrates is now made easier by the newly developed data repository, KANPHOS Signal transduction, or cellular ...
Initially, the DDB1 and CUL4 Associated Factor 1 (DCAF1) was identified as a protein that interacts with human immunodeficiency virus 1 (HIV-1) virion-associated protein (Vpr) and regulates cell ...
Signal transduction pathways comprise the cell's communications system; they transmit cues--from hormones, growth factors, or cytokines, for instance--that tell the cell to proliferate, differentiate, ...
BOSTON--(BUSINESS WIRE)--Photys Therapeutics, the pioneer in the development of phosphorylation-inducing chimeric small molecule medicines (PHICS), founded by Longwood Fund and Dr. Amit Choudhary of ...
A novel proteomics workflow for simultaneous analysis of protein phosphorylation and S-nitrosylation
Combining PAT-switch with nanoLC-MS/MS, this study maps 12,552 phosphorylation and 6,108 SNO sites in Arabidopsis, revealing 968 dual-modified proteins which are functionally enriched in carbon ...
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Phosphorylation enables tau protein to form reversible droplets, offering insights into early Alzheimer's
In a study published in the Journal of the American Chemical Society, scientists explore how a brain protein called tau changes its behavior when a small chemical group called a phosphate attaches to ...
Protein aggregates, damaged organelles, and invading bacteria are identified and removed in healthy cells. An international ...
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