This is a preview. Log in through your library . Abstract This paper introduces a dose-response model for toxic quantal response data based on hit theory applied to the dose unit as transformed by a ...

The discovery of genetic polymorphisms in drug metabolism has contributed significantly to the understanding of the inter-individual variability in dose-concentration relationships and drug response.

Patients receiving second-line or greater therapy 56.4 weeks 46.7 weeks HR = 0.73; p = 0.024 CrEL = Cremphor EL; HR = Hazard ratio; Nab = Nanoparticle albumin bound. Nanoparticle albumin-bound ...

Phase I Clinical and Pharmacokinetic Study of Flavopiridol Administered as a Daily 1-Hour Infusion in Patients With Advanced Neoplasms PURPOSE: N-(3-Chloro-7-indolyl)-1,4-benzenedisulfonamide (E7070) ...