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BMS-986504 demonstrates durable responses in MTAP-deleted NSCLC, including EGFR and ALK-positive tumors
BMS-986504, a first-in-class methylthioadenosine (MTA)-cooperative protein arginine methyltransferase 5 (PRMT5) targeting agent, showed promising antitumor activity in heavily pretreated patients with ...
MTAP encodes methylthioadenosine phosphorylase, an enzyme in the methionine salvage pathway that recycles methylthioadenosine to methionine. The gene resides on chromosome 9p21.3, adjacent to the ...
Homozygous deletions of methylthioadenosine phosphorylase (MTAP) enzyme are common across human cancers and are associated with poor prognoses. Currently, to our knowledge, there are no approved ...
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