Targeting epigenetic mechanisms during initial learning or memory retrieval can lead to persistent memory. Retrieval induces plasticity that may result in reconsolidation of the original memory, in ...

A long-standing hypothesis posits that a G protein-coupled signaling pathway mediates β-adrenergic nervous system functions, including learning and memory. Here we report that memory retrieval ...

The way we experience the present is largely influenced by our memories of the past. Some memories help us navigate the world around us, while others can make life more difficult and uncomfortable.

Reconsolidation theory proposes that retrieval can destabilize an existing memory trace, opening a time-dependent window during which that trace is amenable to modification. Support for the theory is ...

Importantly, once the reconsolidation window had closed and the memory was re-stabilized, the amount of excitation/inhibition returned to baseline levels. This suggests that the changeability of the ...

Researchers have found a mechanism that links epigenetic changes to translational control during fear memory reconsolidation. They report that several particular epigenetic changes in the hippocampus ...

n 1999 a postdoc in my lab, Karim Nader, walked into my office with an idea for a new experiment. He outlined his plan to test a controversial theory in neuroscience called memory reconsolidation that ...

Amy Reichelt receives funding from Leverhulme Trust, Wellcome Trust and Universitas 21. She is affiliated with The University of Birmingham, UK and is a Visiting Fellow at The University of New South ...

Researchers have come up with a way to help prevent recovering drug addicts from relapsing -- without using other pharmaceuticals to help. The approach involves modifying addicts' behavior by ...

In the spring of 1968, experimental psychologist Donald Lewis and his colleagues published a study about memory that was well before its time. The researchers first trained rats to fear a particular ...