Medscape

FDA Adds Boxed Warning for Immune Effector Cell-Associated Enterocolitis to CAR-T Drug

The FDA approved updated labeling for Carvykti (ciltacabtagene autoleucel, Janssen Biotech) to include a new boxed warning for immune effector cell-associated enterocolitis (IEC-EC). Carvykti is a ...

Excellergy to be acquired by Novartis for up to USD 2 billion to advance potentially first-in-class trifunctional effector cell response inhibitors

Exl-111 is a trifunctional ECRI designed to disarm allergic effector cells at the source of activation by targeting the IgE axis. Exl-111 is currently being evaluated in the Phase 1 DISARM trial, a ...
Medscape

New Syndrome With CAR T-Cell Therapy in Autoimmune Diseases

A substantial proportion of patients with autoimmune diseases experienced a new side effect called local immune effector cell–associated toxicity syndromes (LICATS) after receiving chimeric antigen ...
European Medical Journal

CART Cell Therapy Signals Bleeding Risk

The findings are notable because thrombotic complications are often emphasized in cancer care, yet this analysis found that ...