Fans can listen to Monday Night Football live with SiriusXM on channel 88, NFL Radio, for the national broadcast. Team-specific channels are available, with 225 being the Colts and 226 being the 49ers.

Indianapolis Colts host the San Francisco 49ers for NFL Monday Night Football tonight in Week 16. MNF time, TV schedule, how to watch live and streaming.

Indianapolis is on its bye in Week 11, along with the New Orleans Saints. The Colts will return to action in Week 12 when they visit the Kansas City Chiefs on Sunday, Nov. 23. The Colts are one of just two teams on a bye in Week 11 and are the only AFC representative.

It's the San Francisco 49ers vs Indianapolis Colts on Monday Night Football in Week 16 of the 2025 NFL season. Here's how to watch, including time, TV channel and streaming info.

Get the full 49ers practice and media schedule ahead of the Week 16 matchup vs. the Colts, including press conferences with Kyle Shanahan and Brock Purdy.

San Francisco vs. Indianapolis takes place on Monday Night Football, and bettors can use NFL sportsbook promos at the best NFL betting sites and NFL betting apps

The Colts did not hold a practice on Thursday, but they say that cornerback Sauce Gardner would have returned to the field if they did.

The Colts host the 49ers on "Monday Night Football" to wrap up Week 16. Here's where to watch, stream, the start time and predictions.

In three games since Gardner's injury, the Colts are allowing an average of 268.7 yards passing and 34 points per contest. They're also in the midst of a five-game losing streak that has seen them drop almost entirely out of the postseason picture after entering the third week of November with an 8-2 record.