The Horner--Wadsworth--Emmons (HWE) reaction is commonly used in organic chemistry to synthesize conjugated aldehydes. However, traditional HWE reaction methods sometimes have inconsistent (E)- and (Z ...

DNA synthesis is vital to several processes in biopharmaceutical innovation, including the development of gene therapies, CRISPR gene editing, antisense oligonucleotides and RNA therapies. The need ...

RNA drugs are the next frontier of medicine, but manufacturing them requires an expensive and labor-intensive process that limits production and produces metric tons of toxic chemical waste.

Coupling reactions are among the most transformative tools in organic chemistry, enabling the formation of crucial chemical bonds in pharmaceuticals, agrochemicals, and advanced materials. Since their ...

This module explores the synthesis of amines with a focus on the reductive amination reaction. Numerous examples from the discovery and commercial manufacturing of pharmaceuticals are included. After ...

The article provides a comprehensive review of the current progress and future prospects of high-pressure-driven chemical synthesis, offering constructive guidance for the design and development of ...

Heterocyclic compounds are organic molecules with a ring structure comprising at least two or more elements. In most cases, these rings are composed of carbon atoms along with one or more other ...

Scientists have long considered ketones (a fundamental chemical class) and esters (molecules formed when an acid reacts with an alcohol) to be locked treasure chests of possibilities. Ubiquitous as ...

Chemistry is all around us. From the widespread production of global food supplies to the metabolism that fuels the tiniest of microorganisms, everything in our surroundings is produced and controlled ...

There’s been this dream for decades. What if we could just print out an entire gene directly, one base at a time? —Daniel Lin-Arlow, Ansa Biotechnologies As scientists set their sights on cell and ...