The Philadelphia Eagles' quest for a repeat begins now as the reigning Super Bowl champions host the upset-minded San Francisco 49ers in the wild-card round of the 2025 NFL playoffs on FOX.

The San Francisco 49ers upset the Philadelphia Eagles with a remarkable defensive effort and a come-from-behind win.

The featured game of Sunday's slate of NFL Wild Card weekend had the reigning Super Bowl Champion Philadelphia Eagles hosting the San Francisco 49ers

Even after George Kittle was lost to a torn Achilles tendon, San Francisco knocked off the defending Super Bowl champion

Seattle Seahawks quarterback Sam Darnold rips a pass over the middle to wide receiver Jaxon Smith-Njigba who makes an unbelievable adjustment in mid air to haul in the 19-yard catch in Week 18 against the San Francisco 49ers.

Seahawks lead the 49ers 10-3, and San Francisco will get the ball to begin the third quarter. Eddy Pineiro's 48-yard field goal is good, and the 49ers are on the board. Seahawks still lead 10-3 with 1:06 left in the first half.

The San Francisco 49ers just didn’t have the horses to hang with the Seattle Seahawks in their Week 18 matchup.

Purdy found Jauan Jennings for a 38-yard touchdown reception with 2:15 to spare for the 49ers’ much-needed yet seemingly ludicrous seventh touchdown of the night. He threw three touchdown passes and 303 yards, and also ran for two scores to help offset his opening-throw pick-six en route to a sixth straight win.

Follow along with Eagles Wire for live updates, scoring plays, and highlights from the NFC Wild Card clash between the Eagles and 49ers